Spastic Paraplegia-Paget Disease of Bone Syndrome

Spastic Paraplegia-Paget Disease of Bone Syndrome is related to behavioral variant of frontotemporal dementia and frontotemporal dementia. An important gene associated with Spastic Paraplegia-Paget Disease of Bone Syndrome is SQSTM1 (Sequestosome 1), and among its related pathways/superpathways are Nuclear events mediated by NFE2L2 and Selective autophagy. Affiliated tissues include bone and tongue, and related phenotypes are gait disturbance and spastic paraplegia