Spastic Paraplegia 7, Autosomal Recessive (SPG7)

Spastic Paraplegia 7, Autosomal Recessive, also known as spastic paraplegia type 7, is related to optic atrophy 9 and spinocerebellar ataxia, autosomal recessive 14, and has symptoms including leg cramps, pain in lower limb and urgency of micturition. An important gene associated with Spastic Paraplegia 7, Autosomal Recessive is SPG7 (SPG7 Matrix AAA Peptidase Subunit, Paraplegin), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Mitochondrial calcium ion transport. The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and eye, and related phenotypes are spastic gait and abnormal pyramidal sign