Spastic Paraplegia 46, Autosomal Recessive (SPG46)

Spastic Paraplegia 46, Autosomal Recessive, also known as hereditary spastic paraplegia 46, is related to spasticity and paraplegia, and has symptoms including cerebellar ataxia and abnormal pyramidal signs. An important gene associated with Spastic Paraplegia 46, Autosomal Recessive is GBA2 (Glucosylceramidase Beta 2), and among its related pathways/superpathways are Metabolism and Sphingolipid metabolism. Affiliated tissues include brain and cerebellum, and related phenotypes are ataxia and cataract