Suppurative Periapical Periodontitis, also known as periapical abscess, is related to dental pulp necrosis and cerebritis. An important gene associated with Suppurative Periapical Periodontitis is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Extracellular matrix organization and Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Metronidazole and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone and skin.