Spinal Muscular Atrophy Type 0, also known as very severe spinal muscular atrophy, is related to spinal muscular atrophy, type i and neuromuscular disease. An important gene associated with Spinal Muscular Atrophy Type 0 is KLHL40 (Kelch Like Family Member 40), and among its related pathways/superpathways is SARS-CoV-2 modulates host translation machinery. Affiliated tissues include brain, and related phenotypes are muscle and cardiovascular system