Spongiform Encephalopathy with Neuropsychiatric Features, also known as prion disease, is related to prion disease and huntington disease-like 1. An important gene associated with Spongiform Encephalopathy with Neuropsychiatric Features is PRNP (Prion Protein (Kanno Blood Group)). The drugs Quinacrine and Anthelmintics have been mentioned in the context of this disorder. Affiliated tissues include cortex and cerebellum, and related phenotypes are dementia and personality changes