Split-Hand/foot Malformation with Long Bone Deficiency 2, also known as split-hand-foot malformation with long bone deficiency 2, is related to split hand-foot malformation. An important gene associated with Split-Hand/foot Malformation with Long Bone Deficiency 2 is SHFLD2 (Split-Hand/Foot Malformation With Long Deficiency 2). Affiliated tissues include bone.