Splenic Disease, also known as abnormality of the spleen, is related to pulmonary edema and hypersplenism, and has symptoms including hepatosplenomegaly An important gene associated with Splenic Disease is CBS (Cystathionine Beta-Synthase), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include spleen and lymph node, and related phenotypes are endocrine/exocrine gland and liver/biliary system