Splenic Sequestration is related to splenomegaly and hemoglobin c disease. An important gene associated with Splenic Sequestration is THPO (Thrombopoietin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Complement cascade. Affiliated tissues include spleen and liver, and related phenotypes are homeostasis/metabolism and growth/size/body region