Smallpox, also known as ordinary smallpox, is related to vaccinia and plague, and has symptoms including exanthema, fever and pruritus. An important gene associated with Smallpox is IFNG (Interferon Gamma), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Calcium acetate and Sevelamer have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Increased shRNA abundance (Z-score > 2)