Selective Ige Deficiency Disease, also known as selective immunoglobulin e deficiency, is related to immune deficiency disease and hashimoto thyroiditis. An important gene associated with Selective Ige Deficiency Disease is TNFRSF13B (TNF Receptor Superfamily Member 13B), and among its related pathways/superpathways are NF-kappaB Signaling and Extrafollicular and follicular B cell activation by SARS-CoV-2. Affiliated tissues include skin, and related phenotype is neoplasm.