Skin/hair/eye Pigmentation, Variation in, 3, also known as skin/hair/eye pigmentation 3, light/dark skin, is related to melanoma, cutaneous malignant 8 and suppressor of tumorigenicity 3. An important gene associated with Skin/hair/eye Pigmentation, Variation in, 3 is TYR (Tyrosinase). Affiliated tissues include eye and skin.