Short Stature-Delayed Bone Age Due to Thyroid Hormone Metabolism Deficiency is related to thyroid hormone metabolism, abnormal, 1. An important gene associated with Short Stature-Delayed Bone Age Due to Thyroid Hormone Metabolism Deficiency is SECISBP2 (SECIS Binding Protein 2). Affiliated tissues include thyroid and bone, and related phenotypes are abnormal circulating enzyme concentration or activity and decreased circulating free t3