Sacral Agenesis with Vertebral Anomalies (SAVA)

Sacral Agenesis with Vertebral Anomalies, also known as sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome, is related to human immunodeficiency virus type 1 and substance abuse, and has symptoms including back pain, sciatica and acute back pain. An important gene associated with Sacral Agenesis with Vertebral Anomalies is TBXT (T-Box Transcription Factor T). The drugs Magnesium sulfate and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and spinal cord, and related phenotypes are abnormal vertebral morphology and absence of the sacrum