Scleral Disease, also known as scleral diseases, is related to scleromalacia perforans and scleritis, and has symptoms including eye manifestations An important gene associated with Scleral Disease is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism