Sickle Cell Disease (SKCA)

Sickle Cell Disease, also known as sickle cell anemia, is related to hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and acute chest syndrome, and has symptoms including abdominal pain, angina pectoris and chest pain. An important gene associated with Sickle Cell Disease is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Glucose / Energy Metabolism and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Sulfadoxine and Pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include Blood, bone marrow and bone, and related phenotypes are chronic hemolytic anemia and hemolytic anemia