Sick Sinus Syndrome, also known as sinus node dysfunction, is related to familial sick sinus syndrome and cardiac arrhythmia, ankyrin-b-related. An important gene associated with Sick Sinus Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Neuroscience and Cardiac conduction. The drugs Ethanol and Atenolol have been mentioned in the context of this disorder. Affiliated tissues include heart and atrioventricular node, and related phenotypes are homeostasis/metabolism and muscle