Substance Abuse, also known as substance-related disorders, is related to bipolar disorder and cannabis abuse. An important gene associated with Substance Abuse is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Phenytoin Pathway, Pharmacokinetics and Venlafaxine Pathway, Pharmacokinetics. The drugs Olanzapine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include brain and prefrontal cortex, and related phenotypes are nervous system and homeostasis/metabolism