Siberian Tick Typhus, also known as north asian tick typhus, is related to african tick-bite fever and endemic typhus, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Siberian Tick Typhus is PLEKHG4 (Pleckstrin Homology And RhoGEF Domain Containing G4), and among its related pathways/superpathways is Blood group systems biosynthesis. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder.