Retroperitoneal Leiomyosarcoma is related to cutaneous fibrous histiocytoma and myoma, and has symptoms including pain An important gene associated with Retroperitoneal Leiomyosarcoma is RPRD1B (Regulation Of Nuclear Pre-MRNA Domain Containing 1B), and among its related pathways/superpathways is Modulators of TCR signaling and T cell activation. The drugs Doxorubicin and Trabectedin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and smooth muscle.