Retinal Arteries, Tortuosity of, also known as retinal arterial tortuosity, is related to brain small vessel disease 1 with or without ocular anomalies and brain small vessel disease 1. An important gene associated with Retinal Arteries, Tortuosity of is COL4A1 (Collagen Type IV Alpha 1 Chain), and among its related pathways/superpathways are Extracellular matrix organization and Pleural mesothelioma. Affiliated tissues include smooth muscle and heart, and related phenotypes are retinal arteriolar tortuosity and retinal hemorrhage