Reticuloendotheliosis, also known as reticuloendotheliosis, x-linked, is related to hypersplenism and hairy cell leukemia. An important gene associated with Reticuloendotheliosis is RELA (RELA Proto-Oncogene, NF-KB Subunit), and among its related pathways/superpathways are NF-KappaB Family Pathway and IL-1 Family Signaling Pathways. Affiliated tissues include bone marrow and spleen.