Reticulohistiocytic Granuloma, also known as reticulohistiocytoma, is related to non-langerhans-cell histiocytosis and erdheim-chester disease. An important gene associated with Reticulohistiocytic Granuloma is CD1E (CD1e Molecule), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include skin and lymph node.