Restless Legs Syndrome (RLS)

Restless Legs Syndrome, also known as willis-ekbom disease, is related to restless legs syndrome 7 and restless legs syndrome 6, and has symptoms including back pain, headache and pain. An important gene associated with Restless Legs Syndrome is RLS4 (Restless Legs Syndrome 4), and among its related pathways/superpathways are Alpha-synuclein signaling and Iron metabolism disorders. The drugs Suvorexant and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and cingulate cortex.