Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Beta, also known as resistance to thyroid hormone due to a mutation in trb, is related to hypothyroidism, congenital, nongoitrous, 2 and hypothyroidism, congenital, nongoitrous, 3. An important gene associated with Resistance to Thyroid Hormone Due to a Mutation in Thyroid Hormone Receptor Beta is THRB (Thyroid Hormone Receptor Beta). Affiliated tissues include thyroid and pituitary.