Respiratory System Disease, also known as abnormality of the respiratory system, is related to upper respiratory tract disease and respiratory failure, and has symptoms including anoxemia, apnea and pleuritic pain. An important gene associated with Respiratory System Disease is MTM1 (Myotubularin 1), and among its related pathways/superpathways are miRNAs involved in DNA damage response and miRNA role in immune response in sepsis. The drugs Acetazolamide and Candesartan cilexetil have been mentioned in the context of this disorder. Affiliated tissues include lung and skeletal muscle.