Respiratory Failure, also known as acute respiratory failure, is related to neonatal respiratory failure and adult respiratory distress syndrome, and has symptoms including anoxemia, apnea and pleuritic pain. An important gene associated with Respiratory Failure is INPP5E (Inositol Polyphosphate-5-Phosphatase E), and among its related pathways/superpathways are Diseases of glycosylation and Surfactant metabolism. The drugs Digoxin and Amiodarone have been mentioned in the context of this disorder. Affiliated tissues include lung and spinal cord, and related phenotypes are Increased vaccinia virus (VACV) infection and homeostasis/metabolism