Rheumatoid Arthritis, also known as ra, is related to arthritis and autoimmune disease, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and miRNA role in immune response in sepsis. The drugs Naltrexone and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, bone and bone marrow, and related phenotypes are joint stiffness and fatigue