Rectum Carcinoma in Situ, also known as carcinoma in situ of rectum, is related to rectal benign neoplasm and rectum cancer. An important gene associated with Rectum Carcinoma in Situ is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are MAPK-Erk Pathway and PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. Affiliated tissues include rectum, and related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).