Rickets

Rickets, also known as vitamin d deficiency, is related to vitamin d-dependent rickets, type 3 and dent disease 1, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rickets is PHEX (Phosphate Regulating Endopeptidase X-Linked), and among its related pathways/superpathways are Metabolism of steroids and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Dinoprostone and Levocetirizine have been mentioned in the context of this disorder. Affiliated tissues include bone and skin, and related phenotypes are Synthetic lethal with c-Myc after tamoxifen stimulation and homeostasis/metabolism