Queensland Tick Typhus, also known as rickettsia australis spotted fever, is related to spotted fever and rocky mountain spotted fever, and has symptoms including fever, headache and myalgia. An important gene associated with Queensland Tick Typhus is PLEKHG4 (Pleckstrin Homology And RhoGEF Domain Containing G4), and among its related pathways/superpathways is tRNA-uridine 2-thiolation (mammalian mitochondria).