Pyle Disease (PYL)

Pyle Disease, also known as metaphyseal dysplasia, pyle type, is related to intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies and metaphyseal dysplasia. An important gene associated with Pyle Disease is SFRP4 (Secreted Frizzled Related Protein 4). Affiliated tissues include bone and cortex, and related phenotypes are reduced bone mineral density and metaphyseal widening