Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne, also known as papa syndrome, is related to erysipelas and acne. An important gene associated with Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne is PSTPIP1 (Proline-Serine-Threonine Phosphatase Interacting Protein 1), and among its related pathways/superpathways are Infectious disease and Innate Immune System. Affiliated tissues include skin and neutrophil, and related phenotypes are arthritis and fatigue