Pathological Gambling, also known as compulsive gambling, is related to polysubstance abuse and acute stress disorder. An important gene associated with Pathological Gambling is CBS (Cystathionine Beta-Synthase), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Naltrexone and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include prefrontal cortex and brain, and related phenotypes are shRNA abundance <= 50% and nervous system