Postural Orthostatic Tachycardia Syndrome, also known as mitral valve prolapse syndrome, is related to orthostatic hypotension and hypermobile ehlers-danlos syndrome, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Postural Orthostatic Tachycardia Syndrome is SLC44A1 (Solute Carrier Family 44 Member 1), and among its related pathways/superpathways are Signal Transduction and Extracellular matrix organization. The drugs Propranolol and Bisoprolol have been mentioned in the context of this disorder. Affiliated tissues include heart and brain, and related phenotypes are homeostasis/metabolism and growth/size/body region