Pustulosis of Palm and Sole, also known as psoriasis, is related to periodontitis, aggressive, 1 and psoriasis 1, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Pustulosis of Palm and Sole is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Vedolizumab and Dapsone have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related phenotypes are homeostasis/metabolism and immune system