Protein Z Deficiency is related to stroke, ischemic and thrombophilia. An important gene associated with Protein Z Deficiency is PROZ (Protein Z, Vitamin K Dependent Plasma Glycoprotein), and among its related pathways/superpathways are Metabolism of proteins and Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation. Affiliated tissues include spinal cord and endothelial.