Prothrombin Thrombophilia, also known as prothrombin g20210a thrombophilia, is related to thrombophilia due to thrombin defect and portal hypertension. An important gene associated with Prothrombin Thrombophilia is CBS (Cystathionine Beta-Synthase), and among its related pathways/superpathways are Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics and Folate-alcohol and cancer pathway hypotheses. Affiliated tissues include placenta and breast.