Proton-Pump Inhibitor-Responsive Esophageal Eosinophilia, also known as ppi-responsive esophageal eosinophilia, is related to hypereosinophilic syndrome and esophagitis, eosinophilic, 1. The drug Proton Pump Inhibitors has been mentioned in the context of this disorder. Related phenotypes are esophagitis and eosinophilic infiltration of the esophagus