Preretinal Fibrosis, also known as epiretinal membrane, is related to macular holes and vitreous detachment. An important gene associated with Preretinal Fibrosis is RLBP1 (Retinaldehyde Binding Protein 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Nanog in Mammalian ESC Pluripotency. The drugs Midazolam and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include retina and eye, and related phenotypes are cellular and cardiovascular system