Premature Ovarian Failure 8, also known as pof8, is related to spermatogenic failure 61. An important gene associated with Premature Ovarian Failure 8 is STAG3 (STAG3 Cohesin Complex Component). The drugs Polyestradiol phosphate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related phenotypes are premature ovarian insufficiency and decreased serum estradiol