Premature Ovarian Failure 5, is also known as pof5. An important gene associated with Premature Ovarian Failure 5 is NOBOX (NOBOX Oogenesis Homeobox). The drugs Polyestradiol phosphate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related phenotypes are premature ovarian insufficiency and secondary amenorrhea