Primary Lateral Sclerosis, Adult, 1, also known as lateral sclerosis, is related to lateral sclerosis and polykaryocytosis inducer, and has symptoms including upper motor neuron signs An important gene associated with Primary Lateral Sclerosis, Adult, 1 is PLSA1 (Primary Lateral Sclerosis, Adult, 1). The drugs Mexiletine and Cannabidiol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and spinal cord.