Paramyotonia Congenita (PMC)

Paramyotonia Congenita, also known as pmc, is related to myotonia and periodic paralysis, and has symptoms including muscular stiffness and myalgia. An important gene associated with Paramyotonia Congenita is SCN4A (Sodium Voltage-Gated Channel Alpha Subunit 4), and among its related pathways/superpathways are Nervous system development and Activation of cAMP-Dependent PKA. The drugs Lamotrigine and Diclofenamide have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle and tongue, and related phenotypes are dysphagia and neonatal hypotonia