Primary Syphilis, also known as early symptomatic syphilis, is related to syphilis and genital herpes, and has symptoms including syphilitic chancre An important gene associated with Primary Syphilis is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways is Network map of SARS-CoV-2 signaling pathway. The drugs Linezolid and Enzyme Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include tonsil and tongue.