Primary Hypertrophic Osteoarthropathy (PDP)

Primary Hypertrophic Osteoarthropathy, also known as pachydermoperiostosis, is related to hypertrophic osteoarthropathy, primary, autosomal recessive, 1 and secondary hypertrophic osteoarthropathy, and has symptoms including arthralgia, flushing and metatarsalgia. An important gene associated with Primary Hypertrophic Osteoarthropathy is HPGD (15-Hydroxyprostaglandin Dehydrogenase), and among its related pathways/superpathways are Fatty acid metabolism and Beta-2 adrenergic-dependent CFTR expression. The drugs Etoricoxib and Narcotics have been mentioned in the context of this disorder. Affiliated tissues include bone and skin, and related phenotypes are hyperhidrosis and abnormal cortical bone morphology