Parkinson-Dementia Syndrome, also known as progressive supranuclear palsy-parkinsonism syndrome, is related to multiple system atrophy 1 and multiple system atrophy, parkinsonian type. An important gene associated with Parkinson-Dementia Syndrome is MAPT (Microtubule Associated Protein Tau). The drugs Flutemetamol and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include subthalamic nucleus and eye, and related phenotypes are parkinsonism and vertical supranuclear gaze palsy