Progressive Supranuclear Palsy-Progressive Non-Fluent Aphasia Syndrome, also known as progressive supranuclear palsy-apraxia of speech syndrome, is related to supranuclear palsy, progressive, 1. An important gene associated with Progressive Supranuclear Palsy-Progressive Non-Fluent Aphasia Syndrome is MAPT (Microtubule Associated Protein Tau). Affiliated tissues include eye and cortex, and related phenotypes are speech apraxia and spoken word recognition deficit