Peptic Ulcer Disease, also known as peptic ulcer, is related to active peptic ulcer disease and multiple endocrine neoplasia, type i, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Peptic Ulcer Disease is S100A8 (S100 Calcium Binding Protein A8), and among its related pathways/superpathways are Signal Transduction and Gastrin signaling pathway. The drugs Metronidazole and Naproxen have been mentioned in the context of this disorder. Affiliated tissues include small intestine and liver, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism