Peptic Ulcer Perforation, also known as perforated peptic ulcer, is related to duodenal ulcer and peritonitis. An important gene associated with Peptic Ulcer Perforation is S100A8 (S100 Calcium Binding Protein A8), and among its related pathways/superpathways is Secretion of hydrochloric acid in parietal cells. The drugs Carbamide peroxide and Analgesics, Opioid have been mentioned in the context of this disorder. Affiliated tissues include adrenal cortex and liver, and related phenotype is digestive/alimentary.